The Hangover crew heads to Thailand for Stu's wedding. After the disaster of a bachelor party in Las Vegas last year, Stu is playing it safe with a mellow pre-wedding brunch. However, nothing goes as planned and Bangkok is the perfect setting for another adventure with the rowdy group.
Behrani, an Iranian immigrant buys a California bungalow, thinking he can fix it up, sell it again, and make enough money to send his son to college. However, the house is the legal property of former drug addict Kathy. After losing the house in an unfair legal dispute with the county, she is left with nowhere to go. Wanting her house back, she hires a lawyer and befriends a police officer. Neither Kathy nor Behrani have broken the law, so they find themselves involved in a difficult moral dilemma.
The old age pensioners that left at the end of the first film come back to earth to visit their relatives. Will they all decide to go back to the planet where no-one grows old, or will they be tempted to stay back on earth, or will they?
Tabitha, once the placid, gentle and devoted pet, adopts all the characteristics of a ferocious, wild animal following the murder of her mistress. The three guilty people are all trapped by the cat's power and each will come to untimely deaths of horrific proportions without anyone being able to solve the mystery that surrounds their brutal death.